Κάθε φορά που το δέρμα κόβεται ή τραυματίζεται σε όλο το πάχος του η επούλωση καταλείπει μια ουλή. Μερικοί άνθρωποι επουλώνουν καλύτερα από άλλους. Δεν μπορούμε να προβλέψουμε με ακρίβεια ποιοι ασθενείς είναι πιθανόν να κάνουν κακή ουλή αλλά γενικά γνωρίζουμε ότι ασθενείς με πολύ σκούρο δέρμα και ασθενείς στο άλλο χρωματικό άκρο, δηλαδή με φακίδες και κόκκινα μαλλιά, έχουν μεγαλύτερη τάση να εμφανίζουν υπερτροφικές ουλές και χηλοειδή. Μερικές επίσης περιοχές του σώματος είναι πιο επιρρεπείς από άλλες.

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